Similar to my earlier Donkey Kong concept work, here is an idea for a Lego-ized Dr. Mario. The layout is much simpler than in the game.
View of the Dr. Mario title done with some 1 bump wide plates.
Dr. Mario minifig. I do not have a Doctor torso, so I just used a white one.
The three viruses.
Full concept image of Lego-ized Dr. Mario.